It found that maca may have a mild positive effect compared with a placebo. Only one of these studies focused entirely on people with ED. MacaĪn older 2010 review looked at four randomized clinical studies investigating maca’s effect on various sexual conditions, including ED. In addition, research from 2018 compared several herbal dietary supplements for ED and found ginseng to be an effective herbal treatment. A 2021 study notes that it effectively improves ED and reduces fatigue in individuals with prostate cancer. Ginseng is a popular natural supplement for treating ED. It may also help with erections and increase DHEA and testosterone levels.Ī 2021 study suggests that Tribulus terrestris, ginseng, and L-arginine are suitable supplements for improving ED, possibly due to their positive effect on nitric oxide synthesis, which could enhance blood flow in the body. Tribulus terrestris is an herb people have used for centuries to treat ED, as it may increase libido. Some people may use it as a supplement to increase testosterone levels. Pregnenolone is a steroid hormone that helps the body produce other hormones, such as testosterone and DHEA. However, doctors classify this hormone as a performance-enhancing drug, which is why professional athletes are not eligible to take ExtenZe. A 2020 review notes that DHEA supplementation can significantly increase testosterone levels.ĭHEA is known to improve mood, sexual function, and cognitive ability. Dehidroepindrosterone (DHEA)ĭHEA is a steroid hormone that is a precursor to both male and female sex hormones. Research from 2018 found that low folic acid may be a risk factor for ED, while in another study, folic acid supplementation could help improve erectile function in people with ED. Another study found that weight training coupled with zinc supplementation improved testosterone levels. A zinc deficiency may also relate to hypogonadism, where the testes have issues producing the sex hormone testosterone, sperm, or both. ![]() Zinc is a necessary mineral for sperm formation - it works with folic acid to form DNA in sperm. However, both of these were rat studies and may not be applicable to humans. One study suggests that icariin and daily sildenafil could treat neurogenic ED, while another study indicates that icariin may help treat diabetes-associated ED. Its active ingredient, icariin, is a PDE5 inhibitor, which prevents PDE5 from stopping the dilation of arteries in the penis. Horny goat weedĪlso known as yinyanghuo or epimedium, horny goat weed is a herbal medicine popular in China as a treatment for ED. Yohimbe also promotes the release of nitric oxide that dilates blood vessels, allowing more blood into the penis. It works by blocking alpha-2 adrenergic receptors that inhibit erections. A 2018 study notes that yohimbine and ginseng were effective treatments for ED. ![]() YohimbeĪlso known as yohimbine, Yohimbe extract is an herbal supplement from the Pausinystalia johimbe tree that practitioners commonly use in West African medicine for ED. For example, a 2017 study suggests that a 75% GABA and 25% sildenafil mixture may be the most effective combination of these ingredients to help treat ED symptoms. GABA is a neurotransmitter that people may use for ED due to its vasodilatory properties. A similar study reports a similar effect when combining L-arginine with sildenafil, the active ingredient in Viagra. Evidence suggests it may work in combination with other ED ingredients.Ī 2021 study notes that combining phosphodiesterase type 5 (PDE5) inhibitors and L-arginine improved sexual function and testosterone levels more than monotherapy. ![]() L-arginine is an amino acid that may help achieve erections easier and maintain them longer. Some of the active ingredients include: L-arginine The company has a variety of products with different ingredients. ExtenZe is a proprietary herbal blend containing several active ingredients that may help treat ED.
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